The critical role of vestibular graviception during cognitivo-motor development.

We report that mouse pups suffered from a delay in the acquisition of sensorimotor reflexes, spatial olfactory guidance, path integration, and ultrasonic communication, while maternal care remained normal. We demonstrate that development has a critical period dependent on the vestibular otolithic sensory perception of gravity, probably temporally between the somesthetic and visual critical periods. The symptoms expressed by the congenital otolithic-deficient mice are similar to validated mouse models of autism and highlight the significance of vestibular graviception in the pathophysiology of development. PMID: 31220486 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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AbstractFamilies face systemic barriers when deciding on educational services for their children with intellectual and developmental disabilities (IDD), including autism spectrum disorder (ASD). Further, caregiver health and well-being is critical for supporting children with IDD. In addition, research has shown a negative correlation between the quality of special education experiences and caregiver health and well-being. However, the barriers and facilitators to positive special education experiences and health are unclear for Latino parents of children with IDD. By identifying barriers, interventions can be created to a...
Source: Review Journal of Autism and Developmental Disorders - Category: Child Development Source Type: research
AbstractCurrent research indicates that a sizable number of autism spectrum disorder (ASD) cases arise from de novo mutations (DNMs) occurring within the paternal germline, usually in an age-dependent manner. Andrologists have reported that somatic cells and gametes share the same pathologies that generate these DNMs —specifically, DNA hypomethylation caused by oxidative nucleoside base damage. Because many ASD researchers seek to identify genetic risk factors, teams are developing methods of assessing aberrant DNA patterns, such as parental gonadal mosaicism. Several studies propose antioxidant supplementatio n as a...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Faezeh Shahdost-fard, Mahmoud Roushani
Source: Microchemical Journal - Category: Chemistry Source Type: research
Authors: Richa S, Khoury R, JRouhayem J, Chammay R, Kazour F, Bou Khalil R, Kheir W, Choueifaty D, Kouba-Hreich E, Gerbaka B, Adib S Abstract This cross-sectional survey examines the prevalence rate of Autism spectrum disorder (ASD) in 818 children (16-48 months) across all Lebanese regions. Screening was done using the revised form of the Modified-Checklist for Autism in Toddlers. Based on the total score of items failed, children were classified into 3 categories of ASD risk (low, moderate and high). Phone calls follow-up interviews and clinical assessments for diagnosis ascertainment were conducted. Given the ca...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
CONCLUSION: In this context, preventive measures and specialized care are necessary. Thus, it is important to propose a close follow-up to the individuals who have been infected by the virus, in order to set up the earliest care possible. Likewise, in pregnant women, screening of mood disorders during the pregnancy or the postpartum period must be facilitated. The follow-up of the babies born during the pandemic must be strengthened to screen and care for possible neurodevelopmental disorders. PMID: 32928535 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Authors: Musa H, Ismail II, Abdul Rashid NH Abstract Paediatric scurvy is uncommon in the modern age but cases have been reported in children with neurodevelopmental issues and restricted dietary habits. The broad clinical picture is frequently overlooked as primarily other systemic diseases are considered first leading to extensive investigations and delay in diagnosis. A 4-year-old boy with autism and bilateral lower limb pain and refusal to walk is reported. His restricted diet and radiographic findings were highly suggestive of scurvy which was confirmed by the extremely low levels of ascorbic acid. Treatment w...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
Publication date: October 2020Source: Research in Autism Spectrum Disorders, Volume 78Author(s): Laura Fusar-Poli, Emanuele Bisso, Ilaria Concas, Teresa Surace, Silvia Tinacci, Antonio Vanella, Rosaria Furnari, Maria Salvina Signorelli, Lena Nylander, Eugenio Aguglia
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Translational Psychiatry, Published online: 18 September 2020; doi:10.1038/s41398-020-01002-1The influence of choline treatment on behavioral and neurochemical autistic-like phenotype in Mthfr-deficient mice
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractAutism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder. ASD community-based organizations (ASD-CBOs) underutilize or inconsistently utilize evidence-based practices (ASD-EBPs) despite numerous available EBPs to treat ASD. Nonetheless, ASD-CBOs implement changes to practices regularly. Understanding ASD-CBO ’s implementation-as-usual (IAU) processes may assist to develop strategies to facilitate ASD-EBP adoption, implementation and sustainment. A convergent mixed methods (quan + QUAL) design was utilized. Twenty ASD-CBO agency leaders (ALs) and 26 direct providers (DPs),...
Source: Administration and Policy in Mental Health and Mental Health Services Research - Category: Psychiatry Source Type: research
ConclusionsOur findings provide further important insights in the requirement of UBE3A expression during brain development. We found that loss of up to 50% of UBE3A protein during prenatal mouse brain development does not significantly impact the assessed mouse behavioral phenotypes. Together with previous findings, our results indicate that the most critical function for mouse UBE3A lies in the early postnatal period between birth and P21.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
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