Estimation of apparent clearance of valproic acid in adult Saudi patients

Conclusion This model showed significant inter-individual variability between subjects. Our findings showed that patient age, body weight, total daily dose, and cotherapy with carbamazepine and phenytoin are the most significant covariates of valproic acid clearance. Collectively, healthcare providers should take these factors in consideration for optimal valproic acid dosage regimen.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research