Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP

Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic an...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other ha...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
The United States is in an obesity epidemic. Obesity has multiple common comorbid conditions, including lower extremity arthritis. We sought to examine the course of treatment for a population with body mass index (BMI) ≥ 40 kg/m2 and osteoarthritis (OA) of the hip or knee. We investigated decision criteria that influenced arthroplasty surgeons to recommend non-operative management versus total joint arthroplasty (TJA). For those patients who ultimately received TJA, we compared outcomes in this population to tho se with BMI
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
Authors: Safran MR, Bedi A, Byrd JWT, Guanche CA, Ilizaliturri V, Lynch TS, Martin HD, Matsuda DK, McCarthy JC, Philippon MJ, Sampson TG, Suarez-Ahedo C Abstract Hip arthroscopy is one of the most rapidly growing areas in orthopaedic surgery because of increased awareness of nonarthritic hip pathologies, advanced imaging modalities, and advanced techniques to reproducibly manage nonarthritic hip pathologies within a deep soft-tissue envelope and a constrained joint. In addition, more academic medical centers are providing residents with education on hip arthroscopy, and many hip preservation fellowships and courses...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
Authors: Murthi AM, Cox RM, Strelzow JA, Athwal GS, Tashjian RZ, Abboud JA Abstract The management of glenohumeral arthritis in young patients is a challenge given the higher demand for use of the arms, need for longer implant survivorship, and higher postoperative expectations in this patient population. Shoulder arthroplasty is an excellent treatment option for elderly patients with glenohumeral arthritis because this patient population does not have demands as high as those of younger patients with glenohumeral arthritis. Common causes of glenohumeral arthritis in young patients include chondrolysis, inflammator...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
ConclusionReported cases of PTRCT and its surgical repair have both increased substantially over time. Approximately 11.70% of patients with PTRCT undergo either open or arthroscopic procedure as a means of surgical repair. With the growing popularity of arthroscopic procedures for rotator cuff repair, further investigation should be performed to analyze trends and risk factors for PTRCT, a seemingly underrepresented orthopedic condition.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Other: Multiprofessional treatment and Educational Program Associated (EPA+C+BCAA) with supplementation of creatine and BCAA.;   Other: Multiprofessional treatment and Educational Program Associated (EPA+C) with supplementation of creatine only. Sponsor:   University of Sao Paulo General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 12 August 2019Source: Journal of OrthopaedicsAuthor(s): Tetsutaro Abe, Nobuhiro Kaku, Tomonori Tabata, Hiroaki Tagomori, Hiroshi TsumuraAbstractWe aimed to clarify the possibility of using bipolar hip arthroplasty (BHA) for degenerative diseases by examining long-term results postoperatively in 336 hips. Patients’ average age was 61.0 years (range, 34–88 years), and the average follow-up period was 12.5 years (range, 5.0–27.3 years). The 5-year, 10-year, and 20-year Kaplan Meier survival rates (end point: revision) were 92.1%, 81.8%, and 20.1% in the osteoarthritis group...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Isolated patellofemoral joint (PFJ) arthritis has been identified in 10% of the population presenting with symptomatic knee osteoarthritis. Patient selection is important in order to improve survivorship following PF arthroplasty. The purpose of this study was to compare the use of a preoperative bone scan versus an MRI to identify the patient with isolated PF arthritis.
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
You're reading Importance of Yoga: Yoga for Physical and Mental Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Yoga has multi-faceted definitions and terms associated with it and mainly focuses on, strength, and flexibility of the human body to keep it sound and healthy. For the wellness of our mental and physical growth and strength, Yoga has been practiced for ages. Originated in India, this technique has a bright history of over five thousand years. The exercises include a series of stretches and postures...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement mental health stress yoga yoga benefits Source Type: blogs
CONCLUSION: Patients with WD who develop ALF with an NWIS> 11 may survive after treatment with Zn and chelators, without liver transplantation, when they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Osteoarthritis symptoms may improve with long-term Zn and chelator therapy without correlation of liver function in WD. PMID: 31388402 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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