Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC03480C, CommunicationQian Cao, Jing Yang, Hang Zhang, Liang Hao, Gang-Gang Yang, Liang-Nian Ji, Zong-Wan Mao A facile and cheap strategy based on visualized in-cell synthesis of theranostic Zn Schiff base complexes realizes cancer-specific therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research

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Hypoxia‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2. Oncol Rep. 2019 Jun 27;: Authors: Cai M, He P, Fang DL Abstract Disturbed mitochondrial dynamics are closely associated with the progression of different types of cancer including hepatocellular carcinoma (HCC). However, the manner in which mitochondrial dynamics are regulated in HCC remains largely unclear. In the present study, via immunofluorescence, real‑time PCR and western blot analysis, the effects of dynamin‑1‑like (DNM1L) on mitochondrial tr...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Long non‑coding RNA plasmacytoma variant translocation 1 gene promotes the development of cervical cancer via the NF‑κB pathway. Mol Med Rep. 2019 Jul 09;: Authors: Wang C, Zou H, Yang H, Wang L, Chu H, Jiao J, Wang Y, Chen A Abstract The long noncoding RNA plasmacytoma variant translocation 1 gene (LncRNA PVT1) has an important role in tumor occurrence and development, yet the role and underlying molecular mechanisms of this RNA in cervical cancer have not yet been elucidated. In the present study, three cervical cancer cell lines (HeLa, Ca Ski and SiHa) were used to verify how LncRNA PVT1 m...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conclusion: In conclusion, these results suggested that euscaphic acid G from G. longituba showed potential anticancer effects against lung cancer cells via inducing cell cycle arrest and apoptosis, at least partly, through NF-κB signaling pathways.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression c...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Cascade pHe/photo dual ‐sensitive 2,3‐dimethylmaleic anhydride‐masked transactivator of transcription (TAT)‐decorating reactive oxygen species (ROS)‐sensitive Ce6/doxorubicin‐loaded hyperbranched nanoparticles (DTRCD) are explored for direct nucleus ‐targeted drug delivery. The TAT targeting effect ofDTRCD is masked to prolonged circulation and reactivated at tumor tissue to enhance cell uptake and translocation into the perinuclear region. Subsequently,DTRCD generates ROS under illumination to disrupt the nuclear membrane to allow nanoparticle entry and trigger intranuclear drug release. AbstractThe cell nuc...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
In conclusion, WX20120108-induced autophagy relies on activating ROS-Foxo3 pathway, which is independent of IAPs. This finding provides a new insight into the mechanism of IAP antagonist-mediated regulation of autophagy. PMID: 31316176 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharmacol Sin Source Type: research
In conclusion, this study highlights the radio-sensitizing anticancer efficacy of Ova in human metastatic NPC cells, as well as its putative cytoprotective role in normal bronchial cells, for airway surface liquid maintenance and homeostasis during or after radiotherapy. PMID: 31323224 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
In conclusion, TTB inhibited OGD/R-induced astrocytes oxidative stress, at least partially through inhibition of HIF1α and VEGF via Nrf2/HO-1 signaling pathway.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Noncoding RNA (ncRNA) plays a regulatory role in a variety of cellular activities. And long noncoding RNA (lncRNA) is one of the important kinds of ncRNA. Previous studies have shown that various lncRNAs are involved in the progression of cancer. LncRNA plasmacytoma variant translocation 1 (PVT1) is a newly discovered oncogenic factor that has been confirmed to be overexpressed in many cancer cells. Moreover, the role of PVT1 in cancer development is closely linked to microRNAs (miRNAs). PVT1 can act as a "sponge" for miRNAs to inhibit their activities, thereby affecting proliferation, invasion, and angiogenesis ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study,TCF3 ‐HLF mRNA was detectable at a high level during induction therapy in a newly diagnosed t(17;19) ‐ALL case, whileTCF3 ‐PBX1 mRNA was undetectable at the end of induction therapy in most newly diagnosed t(1;19) ‐ALL cases. Using 4 t(17;19)‐ALL and 16 t(1;19)‐ALL cell lines, drug response profiling was analyzed. t(17;19)‐ALL cell lines were found to be significantly more resistant to vincristine (VCR), daunorubicin (DNR), and prednisolone (Pred) than t(1;19)‐ALL cell lines. Sensitivities to three (Pred, VCR, andl‐asparaginase [l‐Asp]), four (Pred, VCR,l‐Asp, and DNR) and five (Pred, VC...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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