Effects of aging on sequential cognitive flexibility are associated with fronto-parietal processing deficits

We examined this question in a system neurophysiological study using EEG and source localization in healthy and elderly adults. We show that elderly people reveal deficient sequential cognitive flexibility. Elderly people encounter increased costs to overcome the inhibition of the lately abandoned task set that becomes relevant again and needs to be re-used. The neurophysiological (EEG) data show that differences in sequential cognitive flexibility between young and elderly people emerge as a consequence of two independent, dysfunctional processes: (i) the ability to suppress task-irrelevant information and (ii) the ability to re-implement a previously abandoned task set during response selection. These independent processes were associated with activation differences in inferior frontal and inferior parietal regions. The study reveals a new facet of cognitive flexibility dysfunctions in healthy elderlies.

Source: Anatomy and Embryology - June 18, 2019 Category: Anatomy Source Type: research