A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F.

A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F.
Talanta. 2019 Oct 01;203:178-185
Authors: Wang Y, Song YF, Zhang L, Dai GG, Kang RF, Wu WN, Xu ZH, Fan YC, Bian LY
Abstract
A fluorescence-enhanced and lysosome-targeted Al3+ probe (1) based on a pyrazole-containing hydrazone was developed in this work. The fluorescent probe 1 displays an OFF-ON fluorescence response to Al3+ in the lysosome pH environment. In addition, the resultant 1-Al3+ complex could act as an ON-OFF fluorescence sensor for F-. Fluorescence imaging shows that 1 is suitable for visualization of Al3+ in lysosomes of HeLa cells.
PMID: 31202324 [PubMed - in process]

Source: Talanta - June 17, 2019 Category: Chemistry Authors: Wang Y, Song YF, Zhang L, Dai GG, Kang RF, Wu WN, Xu ZH, Fan YC, Bian LY Tags: Talanta Source Type: research