Circadian Rhythm Disturbances May Be an Alzheimer's Marker Circadian Rhythm Disturbances May Be an Alzheimer's Marker
Circadian rhythm disturbances in older adults may be markers of Alzheimer disease and its progression, new research suggests.Medscape Medical News
Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Rehana Khatoon, Md. Zeeshan Rasheed, Mahika Rawat, Mohd. Mumtaz Alam, Heena Tabassum, Suhel ParvezAbstractAlzheimers’s disease is one of the alarming neurodegenerative disease and it is of global concern.The hallmarks of the disease are the amyloid beta (Aβ) aggregation and presence of neurofibrillary tangles (NFTs). The interaction of Aβ with macromolecular targets affects the normal cellular functions. The amyloid peptide interaction with cellular surfaces may trigger the intracellular cascades of signalling. Interaction...
CONCLUSIONS: We highlight the frequent presence of amyloid pathology in prodromal LBD in our population, and the probable involvement of different metabolic pathways in the same clinically defined dementia. PMID: 31309997 [PubMed - in process]
AbstractBiomarkers classically studied in Alzheimer ’s disease have been analyzed in numerous central nervous system infections in adults, but there are scarce data on these biomarkers in children. Enteroviruses appear to be the most common cause of aseptic meningitis throughout the world. The aim of the study was to investigate neuroinflammatory p roperties of non-polio enteroviruses by measuring CSF concentrations of biomarkers that are involved in neuropathological pathways of neurodegenerative disorders. We measured Aβ42, t-tau, and S100B concentrations in 42 children with enteroviral meningitis (EM) compare...
The global race to create an inexpensive and accessible blood test for Alzheimer disease is heating up. Experts project that such a test could be available in just a few years.Medscape Medical News
CONCLUSIONS: Our findings imply a shared underlying pathology relating MS and brain volume and suggest cognitive functional declines through the muscle-brain axis. Further longitudinal studies are needed to find possible and related causes of reduced MS and cortical atrophy in patients with dementia. PMID: 31311027 [PubMed - as supplied by publisher]
CONCLUSIONS: Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression. PMID: 31311013 [PubMed - as supplied by publisher]
PET images have uncovered consistently greater accumulation of tau protein...Read more on AuntMinnie.comRelated Reading: PET, MRI show physical activity aids brain health PET links sleep and beta-amyloid accumulation How do seniors react to amyloid-PET results? PET study links menopausal status to Alzheimer's FDG-PET links physical activity to healthy brains
(The Korea Advanced Institute of Science and Technology (KAIST)) KAIST researchers have identified somatic mutations in the brain that could contribute to the development of Alzheimer's disease (AD).
IJERPH, Vol. 16, Pages 2560: The Role of Eicosanoids in Alzheimer’s Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16142560 Authors: Roger G. Biringer Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders known. Estimates from the Alzheimer’s Association suggest that there are currently 5.8 million Americans living with the disease and that this will rise to 14 million by 2050. Research over the decades has revealed that AD pathology is complex and involves a number of cellular processes. In addition to the well-studied...