Secukinumab immunogenicity over 52 weeks in patients with psoriatic arthritis and ankylosing spondylitis.

CONCLUSION: Secukinumab treatment was associated with a low (
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research

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CONCLUSION: Our study confirmed that general risk algorithms mostly underestimate and at times overestimate cardiovascular risk in rheumatic patients. We did not find studies that evaluated models for psoriasis or AS, which further demonstrates a need for research in these populations. PMID: 31416923 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presence of uveitis. We conducted a retrospective study of patients with SpA and AAU (January 2016 –June 2017). Patients were identified using ICD-10 and administrative claim codes, diagnoses were confirmed through chart review. Extracted data included demographics, laboratory, clinical data, treatment and Routine Assessment of Patient Index Data 3 (RAPID3) scores based on Multidimensional Heal th Assessment Questionnaire (MDHA...
Source: Rheumatology International - Category: Rheumatology Source Type: research
CONCLUSIONS: Educational needs vary by diagnostic group, gender and disease duration. These differences merit consideration in the design of patient education interventions. PMID: 31365330 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSION: In this study, switching to a second or third TNFi was associated with significantly lower drug survival and response rates for patients with axial and peripheral PsA subtypes. More successful therapeutic approaches will require considering the impact of gender and obesity on TNFi effectiveness. PMID: 31371659 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
CONCLUSION: Based on our systematic review, the epidemiology of IMIDs among immigrants varies according to native and host countries, immigrant generation, and IMID type. The rapid evolution suggests a role for non-genetic factors and gene-environment interactions. Future studies should focus on these pattern shifts, given implications of rising global burden of IMIDs and immigration. PMID: 31351784 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
AbstractAimInflammatory joint diseases (IJDs) are chronic arthritis, but frequently present with co ‐morbidities of other organs and systems, which is known as extra‐articular manifestations (EAMs). It is still unclear which clinical characteristics or bio‐markers can predict the development of EAMs. The aim of this study was to estimate the proportion of EAMs in southern Chinese patients wi th IJDs and to explore the risk factors.MethodsThis was a retrospective cohort study of a total 1135 IJDs patients, including 788 rheumatoid arthritis (RA) patients, 307 ankylosing spondylitis (AS) patients and 40 psoriatic arthr...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: Limb lymphedema is a rare extra-articular manifestation of spondyloarthritis. Its course appears to be independent of joint disease. Its management is specific and should be associated to that of the rheumatologic disorder. PMID: 31279481 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: September 2019Source: Clinica Chimica Acta, Volume 496Author(s): Xu Zhang, Yaping Yuan, Zhipeng Pan, Yubo Ma, Meng Wu, Jiajia Yang, Renfang Han, Mengya Chen, Xingxing Hu, Rui Liu, Napoleon Bellua Sam, Shengqian Xu, Faming PanAbstractObjectivesPrevious studies found that the interleukin (IL)-17 level was elevated in inflammatory arthritis, but results were inconsistent. This meta-analysis aimed to investigate the association of IL-17 cytokine with osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA).MethodsRelevant studies were searched using databases. ...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Caliskan T, Sirin DY, Karaarslan N, Yilmaz I, Ozbek H, Akyuva Y, Kaplan N, Kaya YE, Simsek AT, Guzelant AY, Ates O Abstract The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment for cases of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and ankylosing spondylitis accompanied by moderate or severe joint pain. ETA was applied to primary cell cultures [annulus fibrosus and nucleus pulposus (NP) from intact intervertebral dis...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
CONCLUSIONS: There are no differences in adherence to biological therapies among patients with  chronic inflammatory arthropathies. Adherence correlates with attendance at outpatient  appointments, but this does not imply an increase in the use of hospital resources. PMID: 31276446 [PubMed - in process]
Source: Farmacia Hospitalaria - Category: Drugs & Pharmacology Authors: Tags: Farm Hosp Source Type: research
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