Larvicidal activity and click synthesis of 2-alkoxyl-2-(1,2,3-triazole-1-yl)acetamide library.

Larvicidal activity and click synthesis of 2-alkoxyl-2-(1,2,3-triazole-1-yl)acetamide library. Comb Chem High Throughput Screen. 2013 Jan 18; Authors: Su NN, Xiong LX, Yu SJ, Zhang X, Cui C, Li ZM, Zhao WG Abstract Heterogeneous copper-in-charcoal-catalyzed click synthesis in 96-well polypropylene filter plates is an efficient method for the rapid generation of  sufficient pure 2-alkoxyl-2-(1,2,3-triazole-1-yl) acetamide derivatives library by simple filtration, which directly assay the products for larvicidal activity against mosquitoes. In this procedure, copper nanoparticles on charcoal were arrayed into each well on a 96-well plate, reagents were delivered using a pipette gun, and a constant temperature shaker bath was used to complete the click reaction in 24-72 hours under temperature-controlled conditions. The results of bioassays indicated that the target compounds possessed excellent larvacidal activities against mosquitoes. In particular, larvacidal activities against mosquitoes of compounds 8 [2, 3] and 8 [7, 1] at 2μg.mL-1 were 100% and 73%, respectively. PMID: 23360208 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research