Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease

Conclusions: These findings suggest that MM-EVs play a pivotal role in the development of severely impaired osteoblast activity, which represents a novel biomarker for the precise diagnosis of MBD and a compelling rationale for exploring MM-EVs as a therapeutic target.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Liming Zhang, Qian Lei, Hongxiang Wang, Cuiwei Xu, Teng Liu, Fancong Kong, Cui Yang, Guoxin Yan, Li Sun, Aiqi Zhao, Wenlan Chen, Yu Hu, Hui Xie, Yulin Cao, Fenfen Fu, Guolin Yuan, Zhichao Chen, An-Yuan Guo, Qiubai Li Tags: Research Paper Source Type: research