Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration

Conclusion: These results revealed the crucial role of the YAP/TAZ-Notch1-NICD axis in liver regeneration. Therefore, BET protein inhibitors must be used in caution in the treatment of hepatic diseases by reason of its suppressive roles in liver regeneration.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Chen Liu, Xiawei Cheng, Juntao Chen, Yao Wang, Xiaoying Wu, Rui Tian, Baoqing Liu, Xianfeng Ding, Qiming Sun, Weihua Gong Tags: Research Paper Source Type: research