Oropharyngeal Cancers in the East and the West – Implications of Aetiopathogenesis on Prognosis and Research

There has been a surge in human papillomavirus (HPV)-positive oropharyngeal cancers (OPCs) in the West. Although the prognosis of HPV-positive OPC is good, de-escalation strategies have so far not been able to confirm comparable cancer control. We examine the strategies implemented across the globe to safely reduce toxicities in HPV-positive disease. HPV-negative OPC has a poorer prognosis and is more prevalent in Eastern countries. We outline the intensification strategies currently used in HPV-negative cancers, with an aim to better prognosis.

Source: Clinical Oncology - June 10, 2019 Category: Radiology Authors: S. Chatterjee, S. Ghosh Laskar, H. Mehanna, C.M. Nutting, I. Mallick Tags: Overview Source Type: research