Imine bond formation: A novel concept to incorporate peptide drugs in self-emulsifying drug delivery systems (SEDDS).

CONCLUSION: According to these findings, the concept of imine bond formation with cinnamaldehyde can be considered as a novel concept for increasing lipophilicity of the hydrophilic antibiotic peptide PMB.
PMID: 31176724 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutics and Biopharmaceutics - June 5, 2019 Category: Drugs & Pharmacology Authors: Dizdarević A, Ari Efiana N, Nhu Quynh Phan T, Matuszczak B, Bernkop Schnürch A Tags: Eur J Pharm Biopharm Source Type: research