Serum and urine interleukin ‐17A levels as biomarkers of disease activity in systemic lupus erythematosus

This study examined the correlations of both serum and urine interleukin ‐17A (IL‐17A) levels with disease activity in systemic lupus erythematosus (SLE). This study was also aimed at determining their sensitivity and specificity as biomarkers of disease activity in SLE.MethodsA cross ‐sectional study was performed involving SLE patients (n = 120 patients) from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Serum and urinary IL‐17A levels were determined by immunoassay while disease activity was assessed using Systemic Lupus Erythematosus Disease Activity Index‐20 00 (SLEDAI‐2K) and British Isles Lupus Assessment Group's 2004 index (BILAG 2004) scores. The correlations between serum and urinary IL‐17A levels with total SLEDAI‐2K and BILAG 2004 scores were determined using bivariate correlation analyses. Receiver operating characteristic curves were calc ulated to determine their sensitivity and specificity as disease activity biomarkers.ResultsBoth serum and urinary IL ‐17A levels correlated with total scores of BILAG 2004, BILAG renal, BILAG mucocutaneous, and SLEDAI‐2K (P  
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Authors: PMID: 31441372 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Tags: Lupus Source Type: research
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Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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Source: NIH Calendar of Events - Category: American Health Source Type: events
Condition:   Lupus Interventions:   Drug: BMS-986165-01;   Drug: BMS-986165 Tablet;   Drug: Famotidine Sponsor:   Bristol-Myers Squibb Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: eLife - Category: Biomedical Science Tags: Biochemistry and Chemical Biology Cancer Biology Source Type: research
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Source: Rheumatic Disease Clinics of North America - Category: Rheumatology Authors: Source Type: research
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