Natalizumab treatment reduces microglial activation in the white matter of the MS brain

Conclusions
TSPO-PET imaging can be used as a tool to assess longitudinal changes in microglial activation in the NAWM and in the perilesional areas in the MS brain in vivo. Natalizumab treatment reduces the diffuse compartmentalized CNS inflammation related to brain resident innate immune cells.

Source: Neurology Neuroimmunology and Neuroinflammation - June 6, 2019 Category: Neurology Authors: Sucksdorff, M., Tuisku, J., Matilainen, M., Vuorimaa, A., Smith, S., Keitilä, J., Rokka, J., Parkkola, R., Nylund, M., Rinne, J., Rissanen, E., Airas, L. Tags: PET, Multiple sclerosis Article Source Type: research