Association of Transcriptional Levels of Folate-Mediated One-Carbon Metabolism-Related Genes in Cancer Cell Lines with Drug Treatment Response

Folate-mediated one-carbon metabolism (OCM), which involves folate and methionine cycles, regulates cellular nutrient status and redistribution of one-carbon units into reactions and processes that are vital for cellular functions (1,2). One-carbon units generated from folic acid and amino acids are used for cellular biosynthesis, regulation of redox status, nucleic acid and protein methylation, and genome maintenance, which are necessary for cell growth and survival (1,3). The folate cycle involves multiple biosynthetic reactions in the cytoplasm, mitochondria, and the nucleus (1,4,5).
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research