Comparison Between Nomograms Used to Define Pediatric Aortic Arch Hypoplasia: Retrospective Evaluation Among Patients Less Than 1 Year Old with Coarctation of the Aorta

AbstractAlthough various modalities are currently in use to define pediatric aortic arch hypoplasia (AAH), there is little uniformity among them. We aimed to determine the inter-rater strength of agreement of the nomograms in a survey of patients less than 1 year old, who had undergone coarctation of the aorta (CoA) repair with or without AAH. This retrospectively designed study comprised of 105 patients with CoA, who had been evaluated between 2008 and 2018 by means of a computed tomography angiogram. Through re-estimation of the aortic arch segmental diameters, thez scores were calculated using three nomograms (Cantinotti, Pettersen, Lopez). Along with at test and Pearson ’s correlation coefficient, a linear regression analysis, Bland–Altman plots, and Cohen’s kappak value were used to evaluate inter-rater strength of agreement. The mean age and weight of the cohort was 73.3  ± 81.2 days and 4.2 ± 1.6 kg, respectively. Sixty-four (61%) patients were neonates. Thez scores of the nomograms for each aortic arch segment were significantly different. Although there was a significantly positive correlation between the nomograms with their related aortic arch diameter, the differences inz scores revealed considerable deviations in the scatter plot diagrams. The mean difference ofz scores was significantly different from the testing value of zero, which was also presented in Bland –Altman plots. None of the comparisons reached a kappak value of >  0.9. T...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research