Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential.

Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential. Monaldi Arch Chest Dis. 2019 May 24;89(2): Authors: Krishnamurthy S, Sivagnaname Y, Gumallapu GC Abstract Adequate cognitive functioning in chronic obstructive pulmonary disease (COPD) patients is essential to understand the nature of the disease, adherence to treatment, and for leading a better quality of life. While cognitive impairment in severe forms of COPD have been well documented, identification of subclinical cognitive impairment in stable COPD patients remains crucial for planning prevention strategies. Hence the present study aimed to study and compare the cognitive function between the COPD patients, and normal individuals. The cognitive function was assessed in 42 stable COPD patients and 42 normal individuals with Mini Mental State Examination (MMSE), and auditory P300 event related potentials. Baseline characteristics and the cognitive parameters were compared between the COPD patients and the normal individuals; a p<0.05 was considered statistically significant. The latency of the P300 waves was significantly (p<0.05) prolonged (304.27±20.73 in COPD, 291.11± 24.53 in normal individuals), and the amplitude (4.36±1.56 in COPD, 5.46±3.12 in normal individuals) was significantly reduced in the COPD patients compared to the normal individuals. MMSE scores were also significantly...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research