Prognostic value of 18F-FDG PET/CT Imaging in Recurrent Salivary Gland Cancers
Conclusions: TLG on restaging FDG-PET predicted PFS and OS in patients with RSGC; patients with predicted poor outcome may benefit from alternate, escalated treatment strategies. Multivariate analysis of clinicopathological and imaging parametersParameterPFS HR (95.0% CI)PFS p-valueOS HR (95.0% CI)OS p-valueHistologic subtype, Adenocarcinoma vs. Non-adenocarcinoma2.27 (1.33- 3.89)0.0031.60 (0.91-2.80)0.09TMTV1.01 (0.99-1.012)0.081.00 (1.00-1.011)0.14TLG1.00 (1.00-1.001)
Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Marc Arbyn, Elisabete Weiderpass, Laia Bruni, Silvia de Sanjosé, Mona Saraiya, Jacques Ferlay, Freddie BraySummaryBackgroundThe knowledge that persistent human papillomavirus (HPV) infection is the main cause of cervical cancer has resulted in the development of prophylactic vaccines to prevent HPV infection and HPV assays that detect nucleic acids of the virus. WHO has launched a Global Initiative to scale up preventive, screening, and treatment interventions to eliminate cervical cancer as a public health problem during th...
Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Afsan Bhadelia
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
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ConclusionAlthough the objective responses to eribulin were uncommon, disease control was observed in the majority of patients.
Salivary gland cancers (SGCs) are uncommon diseases accounting for only 2 –6.5% of all head and neck cancers, and are characterized by considerable variability in their biology and natural history . Mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and adenocarcinoma are the most frequent diagnoses, representing> 75% of all SGCs, although their frequency varies according to the site of origin (major vs minor salivary glands) . Prognosis among SGCs differs according to histology and grading: non-ACC and high-grade tumors are associated with a poorer prognosis compared with low-grade tumors [3 –5].
Conclusion: These results indicate that hormone therapy used in breast cancer may also be effective for ER-positive SAC.
Objectives/HypothesisWe sought to better characterize patient, tumor, and long‐term survival characteristics of basal cell adenocarcinoma (BCAC) of the major salivary glands with the National Cancer Database (NCDB). Study DesignRetrospective database review of the NCDB (1998–2012). MethodsWe retrospectively reviewed the NCDB for all cases of major salivary gland BCAC with histologic code 8147/3. Relevant demographic, tumor, and survival variables were extracted and analyzed. COX multivariate regression was performed to identify prognosticators. ResultsOut of 36,224 major salivary gland cancers in the NCDB, we found...
Conclusion Salivary gland carcinomas show a high expression of pEGFR. This high expression correlates with lymph node metastasis, which supports the hypothesis that a high pEGFR expression facilitates lymphogenous metastasis. Due to this pEGFR expression, status may be a negative predictive factor in salivary gland carcinoma diagnostics. Patients with pN-positive salivary gland cancer may benefit from EGFR-inhibiting drugs. Clinical relevance The EGFR pathway may be a potential target for chemotherapy of advanced unresectable salivary gland carcinomas.
In conclusion, our novel finding of metformin efficacy in SGC not only proves metformin plays a pivotal role in suppressing SGCs through cell cycle arrest and apoptosis, but also suggest that a combination treatment using metformin and mTOR inhibitors together may yield better inhibitory efficacy.Citation Format: Yuqi Guo. Metformin inhibits salivary gland tumor growth through cell cycle arrest and apoptosis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3492. doi:10...