Synthesis and evaluation of 68Ga-NOTA-ZIGF-1R:4:40 in IGF-1R targeted molecular imaging in lung cancer

Conclusions: New IGF-1R targeted probe,68Ga-NOTA-ZIGF-1R:4:40, was synthesized successfully. And it could distinguish different IGF-1R expression levels, which was expected to guide IGF-1R targeted therapy and evaluate treatment efficacy in real time noninvasively.A large number of verification experiments were still needed to be studied. REFERENCE: [1] Coppola D, Ferber A, Miura M, et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol. 1994;14(7):4588-4595. [2] Baserga R. The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets. 2005;9(4):753-76. [3] Hye-Young Min, Hye Jeong Yun, Ji-Sun Lee, et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer Mol Cancer. 2015; 14: 113.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology Posters Source Type: research