Snapshot of chikungunya could lead to drugs, vaccines for viral arthritis

(Washington University School of Medicine) A team at Washington University School of Medicine in St. Louis has snapped high-resolution pictures of chikungunya virus latched onto a protein found on the surface of cells in the joints. The structures, published May 9, 2019 in the journal Cell, shows in atomic-level detail how the virus and cell-surface protein fit together -- data that promises to accelerate efforts to design drugs and vaccines to prevent or treat arthritis caused by chikungunya or related viruses.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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alérie Choumet Arboviruses like chikungunya and Ross River (RRV) are responsible for massive outbreaks of viral polyarthritis. There is no effective treatment or vaccine available against these viruses that induce prolonged and disabling arthritis. To explore the physiopathological mechanisms of alphaviral arthritis, we engineered a recombinant RRV expressing a NanoLuc reporter (RRV-NLuc), which exhibited high stability, near native replication kinetics and allowed real time monitoring of viral spread in an albino mouse strain. During the acute phase of the disease, we observed a high bioluminescent signal refle...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Tapas Kumar Nayak1†, Prabhudutta Mamidi2, Subhransu Sekhar Sahoo1, P. Sanjai Kumar1, Chandan Mahish1, Sanchari Chatterjee2, Bharat Bhusan Subudhi3, Soma Chattopadhyay2 and Subhasis Chattopadhyay1* 1School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India2Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, India3School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, India Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the maj...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Purpose: We have developed a live recombinant measles vector-based vaccine to prevent Chikungunya disease (MV-CHIK). Previously, the safety and immunogenicity was demonstrated in a Phase 1 clinical trial (EudraCT: 2013-001084-23). Here, we will present the final data of a Phase 2 clinical trial in 263 healthy, volunteer adults (NCT02861586). Chikungunya is a rapidly spreading viral disease affecting significant parts of the Americas, India and South East Asia. In the majority of patients, the febrile acute disease turns into a chronic disease causing severe, debilitating arthritis that can last years post-infection.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.080 Source Type: research
Authors: McCarthy MK, Davenport BJJ, Morrison TE Abstract Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has caused both small- and large-scale epidemics of incapacitating musculoskeletal disease across the globe. A substantial proportion of infected individuals experience debilitating arthralgia and/or arthritis that can persist in relapsing or continuous forms for months to years, an occurrence that appears independent of viral strain and outbreak location. Due to the lack of CHIKV-specific vaccine or therapeutics, treatment of chronic CHIKV disease is limited to supportive care. Although the...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
In conclusion, the ability of silymarin to inhibit MAYV replication and attenuate MAYV-induce oxidative stress warrants further investigation of this compound as a novel therapeutic approach to Mayaro fever disease.
Source: Antiviral Therapy - Category: Virology Source Type: research
In conclusion, the ability of silymarin to inhibit MAYV replication and attenuate MAYV-induce oxidative stress warrants further investigation of this compound as a novel therapeutic approach to Mayaro fever disease. PMID: 30076863 [PubMed - as supplied by publisher]
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Authors: Moizéis RNC, Fernandes TAAM, Guedes PMDM, Pereira HWB, Lanza DCF, Azevedo JWV, Galvão JMA, Fernandes JV Abstract Chikungunya fever is an emerging arbovirus infection, representing a serious public health problem. Its etiological agent is the Chikungunya virus (CHIKV). Transmission of this virus is mainly vector by mosquitoes of the genus Aedes, although transmission by blood transfusions and vertical transmission has also been reported. The disease presents high morbidity caused mainly by the arthralgia and arthritis generated. Cardiovascular and neurological manifestations have also been rep...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Authors: Runowska M, Majewski D, Niklas K, Puszczewicz M Abstract Chikungunya virus (CHIKV) is an arthropod-borne alphavirus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes. It is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. The disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (RA). The underlying mechanism by which CHIKV induces persistent arthritis remains under investigation, however, currently, atte...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
FINDINGSA new study demonstrates that outbreaks of mosquito-borne viruses Zika and Chikungunya generally occur about three weeks after heavy rainfall.Researchers also found that Chikungunya will predominate over Zika when both circulate at the same time, because Chikungunya has a shorter incubation period — just two days, versus 10 days for Zika. The latter finding explains why a late-2015 Zika epidemic in Rio de Janeiro ended while the number of Chikungunya cases increased in February 2016.BACKGROUNDViruses transmitted by insects can lead to serious health repercussions. Zika is linked to birth defects, and up to 1 ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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