AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose- and albumin-induced epithelial-mesenchymal transition.
In conclusion, AMPK activation might be beneficial in attenuating the tubulointerstitial fibrosis induced by TGF-β, angiotensin II, aldosterone, high glucose and urinary albumin.
PMID: 23324179 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Lee JH, Kim JH, Kim JS, Chang JW, Kim SB, Park JS, Lee SK Tags: Am J Physiol Renal Physiol Source Type: research