Immediate Pre-Learning Stress Enhances Baseline Startle Response and Fear Acquisition in a Fear-Potentiated Startle Paradigm.

Immediate Pre-Learning Stress Enhances Baseline Startle Response and Fear Acquisition in a Fear-Potentiated Startle Paradigm. Behav Brain Res. 2019 May 27;:111980 Authors: Riggenbach MR, Weiser JN, Mosley BE, Hipskind JJ, Wireman LE, Hess KL, Duffy TJ, Handel JK, Kaschalk MG, Reneau KE, Rorabaugh BR, Norrholm SD, Jovanovic T, Zoladz PR Abstract Extensive work has shown that stress time-dependently influences hippocampus-dependent learning and memory. In particular, stress that is administered immediately before learning enhances long-term memory, while stress that is temporally separated from learning impairs long-term memory. We have extended these findings by examining the impact of immediate, pre-learning stress on an amygdala-dependent fear conditioning task. One hundred and forty-one healthy participants underwent a stress (socially evaluated cold pressor test) or control manipulation immediately before completing differential fear conditioning in a fear-potentiated startle paradigm. Participants then completed extinction and extinction memory testing sessions 24 and 48 h later, respectively. Stress administered immediately before acquisition increased baseline startle responses and enhanced fear learning, as evidenced by greater fear-potentiated startle to the CS + . Although no group differences were observed during extinction training on Day 2, stressed participants exhibited evidence of impaired extinction processes on Day 3...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Authors: Averell CM, Stanford RH, Laliberté F, Wu JW, Germain G, Duh MS Abstract Objective: This real-world observational study compared medication adherence and persistence among patients with asthma receiving the once-daily inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fluticasone furoate/vilanterol (FF/VI) versus the twice-daily ICS/LABAs budesonide/formoterol (B/F) and fluticasone propionate/salmeterol (FP/SAL). Methods: This retrospective cohort study conducted using IQVIATM Health Plan Claims Data included patients with asthma ≥18 years of age initiating ICS/LABA therapy with ...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
ConclusionMacrophage activation syndrome is a rare entity, rarely reported during primary Sj ögren’s syndrome. Its spontaneous evolution is invariably fatal. There is no consensus on therapeutic treatment. Etoposide is a therapeutic option especially in forms refractory to corticosteroid therapy.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
We report a case series of 4 patients of alopecia areata treated with systemic azathioprine monotherapy.
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
Publication date: Available online 14 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): M. Yanagidaira, T. Hattori, H. Emoto, M. Kiyosawa, T. YokotaAbstractA 25-year-old male presented with blurred peripheral vision and movement pain in his right eye. Fundus examination revealed unilateral disc swelling in his right eye with normal intracranial pressure. MRI showed remarkably high intensity in the optic nerve sheath and slightly high intensity in the optic nerve, indicating optic perineuritis (OPN). Anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive in both serum and cerebrospinal flu...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusions: Esophageal involvement of LP is frequent, but may be asymptomatic. ELP can be diagnosed using the diagnostic criteria proposed here. Dysphagia and combined oral and genital manifestation are associated with ELP. Therapy with topical corticosteroids appears to be a prudent therapeutic approach for ELP. PMID: 31608788 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Condition:   Oral Lichen Planus Interventions:   Dietary Supplement: topical corticosteroids and vitamin E suplements;   Drug: Topical corticosteroid and placebo capsules Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Oral Lichen Planus Interventions:   Dietary Supplement: topical corticosteroids and vitamin E suplements;   Drug: Topical corticosteroid and placebo capsules Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
X-ray imaging shows that corticosteroid injections for osteoarthritis pain...Read more on AuntMinnie.comRelated Reading: 3D MRI helps predict osteoarthritis risk after ACL tears 3 ways to reduce unnecessary MRI knee scans 6 ways AI will enhance musculoskeletal imaging Many knee MRI scans may not be clinically indicated New 3D CT technique tops x-ray for diagnosing arthritis
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
TUESDAY, Oct. 15, 2019 -- Corticosteroid shots are often used to ease arthritis pain, but a new study suggests they may be riskier than thought. Researchers found that among patients who had the treatment at their center, 8% had complications. Most...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
In this study, we sought to identify characteristics that would be predictive of efficacy for this combination r egimen.MethodsSixty ‐four patients with CRS, bilateral polyps, a polyp score of at least 3, and a 22‐item Sino‐Nasal Outcome Test (SNOT‐22) score ≥20 were prospectively enrolled and uniformly treated with a 15‐day prednisone taper and twice daily dilute budesonide irrigations. Participants were assessed at enrollment and at follow up, 2 to 5 months later. Clinical and demographic characteristics were assessed at enrollment. At both time points, CRS symptoms were assessed with SNOT‐22, and polyp sc...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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