Cardiovascular determinants of resuscitation from sepsis and septic shock

We hypothesized that the cardiovascular responses to Surviving Sepsis Guidelines (SSG)-defined resuscitation are predictable based on the cardiovascular state. The cardiovascular response to SSG-based resuscitation is highly heterogeneous but predictable from pre-treatment measures of cardiovascular state.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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AbstractVibrio vulnificus is a Gram-negative bacterium that belongs to the Vibrionaceae family. It represents a deadly opportunistic human pathogen which grows in water with the proper temperature and salinity, and is mostly acquired from seafood eating or direct contact. In susceptible individuals, a traumatic infection could be fatal, causing severe wound infection and even septic shock, and may require amputation. Global warming plays an important role in the geographical area expanding of Vibrio disease. The pathogenesis ofVibrio vulnificus–associated sepsis is very complex, including iron intake, cell injury, an...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
(Natural News) Survivors of septic shock often experience memory loss and premature cognitive decline. While this is a known and established occurrence, the cause of this cognitive impairment is unknown. But in a new study published in The Proceedings of the National Academy of Sciences, American researchers finally shed light on what causes the loss of...
Source: - Category: Consumer Health News Source Type: news
Contributors : Andrew C Sayce ; Joanna L Miller ; Fernando O Martinez ; Raymond A Dwek ; Nicole ZitzmannSeries Type : Expression profiling by arrayOrganism : Homo sapiensProtocols for the treatment of sepsis and septic shock are restricted to early administration of appropriate antibiotics and supportive organ care. To date, there has been limited success in addressing the characteristically dysregulated host response once it is underway. Furthermore, virus-induced sepsis remains poorly appreciated, and treatment strategies are similarly limited to supportive measures. Prior in vitro and murine studies demonstrate antivira...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conclusion and Relevance: First-line vasopressin exhibited faster time to distributive shock reversal in the unadjusted analysis but failed to maintain this difference in the multivariable analysis. These findings support safe use of vasopressin as first-line therapy or as an alternative to norepinephrine in distributive shock. PMID: 31625395 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - Category: Drugs & Pharmacology Authors: Tags: Ann Pharmacother Source Type: research
Condition:   Sepsis, Septic Shock Interventions:   Drug: Neostigmine;   Drug: Standard therapy Sponsor:   Mansoura University Recruiting
Source: - Category: Research Source Type: clinical trials
In conclusion, the modulation of RNS may be considered an effective adjunct therapy for septic shock, in the case of hypo-responsiveness to norepinephrine.
Source: Shock - Category: Emergency Medicine Tags: Online Articles Source Type: research
Conclusion: Hydrocortisone administered by intermittent bolus was associated with higher shock reversal at day 7 compared with a continuous infusion.
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Publication date: Available online 15 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Edward D. Chan, Michael M. Chan, Mallory M. Chan, Paul E. MarikAbstractGlucocorticoids (GC) in all its various forms and formulations are likely one of the most commonly used pharmacologic agents in medicine. Their use can be profoundly therapeutic but are also associated with a myriad of acute and chronic side effects. It is fairly well-accepted in the medical community that GC can be life-saving when used in critically ill patients with severe exacerbations of asthma and chronic obstructive pulmonary disease, HIV-associated...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
In this study, we found that treatment of porphyran suppressed LPS-induced upregulation of costimulatory molecule and C-C chemokine receptor type 7 (CCR7) expression in bone marrow-derived dendritic cells (BMDCs) in vitro and spleen DCs in vivo. Moreover, the LPS-induced expression of IL-6, IL-12, and TNF-α in the culture medium of BMDCs and serum dose-dependently decreased by porphyran treatment, which contributed to the inhibition of the intracellular cytokine production in spleen DCs. In addition, LPS-induced differentiation of helper T1 (Th1) and cytotoxic T1 (Tc1) cells was effectively suppressed by porphyran tr...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Editor's Summary by Howard Bauchner, MD, Editor in Chief of JAMA, the Journal of the American Medical Association, for the October 15, 2019 issue
Source: JAMA: This Week's Audio Commentary - Category: General Medicine Authors: Source Type: podcasts
More News: Cardiology | Cardiovascular | Health | Heart | Septic Shock