Associations of regional amyloid- β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults

In conclusion, Aβ plaque or p-tau pathology in different brain regions was predicted by different sets of biological factors. Aβ plaques in prefrontal neocortex and putamen predicted poorer funct ioning in cognitive domains relevant to these brain regions. The absence of significant impact of regional p-tau lesions on neuropsychological functioning might be explained by the subthreshold burden of p-tau lesions.
Source: Journal of NeuroVirology - Category: Neurology Source Type: research