Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells

The bcr-abl fusion gene encodes BCR-ABL oncoprotein and plays a crucial role in the leukemogenesis of chronic myeloid leukemia (CML). Current therapeutic methods have limited treatment effect on CML patients w...

Source: Journal of Experimental and Clinical Cancer Research - May 28, 2019 Category: Cancer & Oncology Authors: Zhenhong Luo, Miao Gao, Ningshu Huang, Xin Wang, Zesong Yang, Hao Yang, Zhenglan Huang and Wenli Feng Tags: Research Source Type: research