Where to Look and How to Look: Combining Global Sensitivity Analysis with Fast/Slow Analysis to Study Multi-Timescale Oscillations.

In this study, we combine the two techniques in the analysis of bursting behavior in a model of insulin-secreting pancreatic β-cells, with the goal of determining the key parameters setting the period of the bursting oscillations, and understanding why they are so influential. This can be viewed as a case study for combining mathematical techniques to build on the strengths of each and thereby achieve a better understanding of what most influences the range of model behaviors and how this influence is brought about.
PMID: 31128125 [PubMed - as supplied by publisher]

Source: Mathematical Biosciences - May 21, 2019 Category: Statistics Authors: Aggarwal M, Cogan N, Bertram R Tags: Math Biosci Source Type: research