Somatic mutation and clonal expansions in human tissues

Editorial summaryRecent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.

Source: Genome Medicine - May 27, 2019 Category: Genetics & Stem Cells Source Type: research