Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial.

Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial.
Comb Chem High Throughput Screen. 2013 Jan 16;
Authors: Verma A, Yadav MR, Giridhar R, Prajapati N, Tripathi AC, Saraf SK
Abstract
The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.
PMID: 23330874 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - January 16, 2013 Category: Chemistry Authors: Verma A, Yadav MR, Giridhar R, Prajapati N, Tripathi AC, Saraf SK Tags: Comb Chem High Throughput Screen Source Type: research