Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial.

Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial. Comb Chem High Throughput Screen. 2013 Jan 16; Authors: Verma A, Yadav MR, Giridhar R, Prajapati N, Tripathi AC, Saraf SK Abstract The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years. PMID: 23330874 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

Related Links:

Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print.
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - Category: Surgery Authors: Source Type: research
Publication date: January 2020Source: The American Journal of Surgery, Volume 219, Issue 1Author(s):
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: January 2020Source: The American Journal of Surgery, Volume 219, Issue 1Author(s):
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: January 2020Source: The American Journal of Surgery, Volume 219, Issue 1Author(s):
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsOpTrust demonstrated a positive association between ACGME general surgery Milestones and OSATS scores. Overall, OpTrust may help optimize intraoperative faculty entrustment and resident entrustability, facilitating surgical trainee success during residency.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 12 December 2019Source: The American Journal of SurgeryAuthor(s): Beiqun Zhao, Nicole E. Lopez, Samuel Eisenstein, Gabriel T. Schnickel, Jason K. Sicklick, Sonia L. Ramamoorthy, Bryan M. ClaryABSTRACTBackgroundThe role of laterality for patients with synchronous metastatic colon cancer (SMCC) is not well-defined.MethodsUsing the National Cancer Database (2010-2015), we compared patients with metastatic right- (RCC) versus left-sided colon cancer (LCC). We performed Kaplan-Meier analysis to compare overall survival (OS) for each metastatic site and utilized adjusted Cox proportional hazard...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Source: American Journal of Surgery - Category: Surgery Source Type: research
Source: American Journal of Surgery - Category: Surgery Source Type: research
Source: American Journal of Surgery - Category: Surgery Source Type: research
This article provides a description of recent activities to address the local opioid crisis, a rationale for their adoption and the context in which they are being undertaken. PMID: 31825786 [PubMed - in process]
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research
More News: Chemistry | Databases & Libraries | Molecular Biology