Structure, mechanism, and inhibition of A/M2-S31N [Chemistry]

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and shows greatly decreased...

Source: Proceedings of the National Academy of Sciences - January 22, 2013 Category: Science Authors: Wang, J., Wu, Y., Ma, C., Fiorin, G., , Pinto, L. H., Lamb, R. A., Klein, M. L., DeGrado, W. F. Tags: Biological Sciences Source Type: research