Live-Animal Epigenome Editing: Convergence of Novel Techniques

Publication date: Available online 22 May 2019Source: Trends in GeneticsAuthor(s): J. Antonio Gomez, Ulrika Beitnere, David J. SegalEpigenome editing refers to the generation of precise chromatin alterations and their effects on gene expression and cell biology. Until recently, much of the efforts in epigenome editing were limited to tissue culture models of disease. However, the convergence of techniques from different fields including mammalian genetics, virology, and CRISPR engineering is advancing epigenome editing into a new era. Researchers are increasingly embracing the use of multicellular model organisms to test the role of specific chromatin alterations in development and disease. The challenge of successful live-animal epigenomic editing will depend on a well-informed foundation of the current methodologies for cell-specific delivery and editing accuracy. Here we review the opportunities for basic research and therapeutic applications.
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research