Link between Endometriosis, Atherosclerotic Cardiovascular Disease, and the Health of Women Midlife

Publication date: Available online 25 April 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Omur Taskin, Kiran Rikhraj, Justin Tan, Tara Sedlak, Timothy C. Rowe, Mohamed A. BedaiwyAbstractEndometriosis and atherosclerotic cardiovascular disease (ASCVD) are both essentially diseases of inflammation. It is well established that inflammation is the leading mechanism in the initiation and maintenance of vascular injury and in the development and progression of atherosclerosis. Thus, if women with endometriosis do indeed have increased general inflammation, they are at increased risk of developing microvascular dysfunction and atherosclerosis. Currently available evidence suggests that young female patients with proven endometriosis may be at a higher lifetime risk of developing cardiovascular disease; this may be unrecognized due to the relatively young age of women found to have endometriosis. Other mechanisms proposed to explain the link between endometriosis and ASCVD include similarities in the genetic underpinnings of each condition, including microRNA dysfunction and the association between endometriosis and early menopause, a risk for developing ASCVD. Although physicians today primarily focus on traditional risk factors when evaluating an individual female patient's risk of developing ASCVD, we believe that a history of endometriosis should be included as a possible risk factor and needs further exploration. A better understanding of the mechanisms linking ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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Authors: Luna Russo MA, Chalif JN, Falcone T Abstract Endometriosis is a disease of reproductive age women that is commonly characterized by symptoms that often negatively impact quality of life. The clinical management of endometriosis remains highly variable and mostly influenced by geographic location, practice patterns, and breadth of clinician experience. This variability in treatment has inspired a trend towards multidisciplinary and specialized care of patients suffering from this disease. Surgical sampling, followed by histologic confirmation of endometrial-like tissue, remains the standard for the definiti...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
AbstractThoracic endometriosis-related pneumothorax (TERP) or thoracic endometriosis syndrome (TES) usually occurs in women of childbearing age and affects the right thorax. Menopausal and left-sided cases are rare. A case of left-sided TERP in a postmenopausal woman after adjuvant endocrine therapy for breast cancer is reported. A 51-year-old woman underwent video-assisted thoracic surgery for recurrent left pneumothorax. Immunohistological examination of the resected specimen from the apical bleb and a diaphragmatic blueberry spot demonstrated thoracic endometriosis. Even in the case of a left-sided pneumothorax in a men...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSION: Long- term Triptorelin plus Tibolone add-back therapy in women suffering from CCPP does not appear to be associated with significant serious adverse events apart from the possibility of deterioration in the BMD that needs to be monitored. This mode of therapy appears to be effective in pain relief and in improving quality of life over a 24-month period. TRIAL REGISTRATION: Clinical trials database NCT00735852. PMID: 32290838 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Conclusion: It is mandatory to point out that our conclusions are valid for patients with ovarian advanced endometriosis but normal ovarian functions. These results suggest three different progestins protocols are equivalent in terms of pregnancy outcomes for women with advanced endometriosis. PPOS protocol can be an alternative choice for women with severe endometriosis and normal ovarian reserve in IVF/ICSI treatment. These methods could be tested with other populations of women with endometriosis.Clinical Trial Registration:www.ClinicalTrials.gov, identifier:ChiCTR-OIN-16008529.Trial registration date: 2014-05-25.Date o...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractPurposeEndocrine disrupting compounds (EDCs) have been shown to affect multiple biologic processes especially steroid-hormone processes. We sought to determine differences in DNA methylation exists between women with and without endometriosis following exposure to polybrominated biphenyl (PBB).MethodsCross-sectional study of 305 females in the Michigan PBB Registry. DNA was extracted, and DNA methylation was interrogated using the MethylationEPIC BeadChip (Illumina, San Diego, California). Demographic data was analyzed using Chi-squared andT tests. Linear regressions were performed for each cytosine-guanine dinucle...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Jade Spargo, from Truro, Cornwall, has suffered from adenomyosis and endometriosis since the age of 16. The conditions left her bed-bound whenever she was on her period.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Cardiovascular diseases are become the primary cause of death in women. The cardiovascular risk of the woman has unknown specificities and remains underestimated. At equal age, women have more cardio vascular risk factors than men. All these specificities must be taken into account for an optimized evaluation of cardiovascular risk and for improvement of CV management in women. Some traditional risk factors are more deleterious in women such as hypertension, tobacco, diabetes or psycho-social stress and they are less well controlled compared to men. Women are also exposed to hormonal risk factors (contrac...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
Authors: Istrate-Ofiţeru AM, Pîrvan IC, Pirici D, Roşu GC, Niculescu M, Berceanu S, Manolea MM, Comănescu MV, Voicu NL, Iovan L, Vasile MM, Căpitănescu RG, Diţescu D, Mogoantă L, Berceanu C Abstract Adenomyosis is a benign pathology, common to both women at reproductive age as well as later during menopause. This condition is accompanied by a strong symptomatology, which has induced intense research on this topic. From a morphological point of view, it is represented by the existence of endometrial glands and, sometimes, of the periglandular stroma (endometriosis) in the structure of the myometrium, at...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Chanelle Urquhart, a bartender who lives in Hull, has endometriosis, an agonising condition where tissue similar to the lining of the womb starts to grow in other places.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Most women experience the menopause between the ages of 45 and 55 – in other words, while they’re working. Given that women make up more than 70% of UNISON’s 1.3 million members, it’s clearly a workplace issue and therefore a union issue that we should be leading the way on. The menopause is a natural transition stage in most women’s lives, usually lasting between four and eight years, although it can be longer. It’s primarily marked by hormonal changes and the end of periods, which can also trigger a wide range of physical and psychological symptoms. The menopause can also occur earlier...
Source: UNISON meat hygiene - Category: Food Science Authors: Tags: Article black members disabled members Menopause unison women Source Type: news
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