Comparison of Techniques for Involved-Site Radiation Therapy in Patients with Lower Mediastinal Lymphoma

Publication date: Available online 22 May 2019Source: Practical Radiation OncologyAuthor(s): Ashlyn S. Everett, Bradford S. Hoppe, Debbie Louis, Andrew M. McDonald, Christopher M. Morris, Nancy P. Mendenhall, Zuofeng Li, Stella FlampouriAbstractIntroductionPatients with lower mediastinal lymphoma (LML) benefit dosimetrically from proton therapy (PT) compared with intensity-modulated radiotherapy (IMRT). The added dosimetric benefit of deep-inspiration breath-hold (DIBH) is unknown; therefore, we evaluated IMRT versus PT and free-breathing (FB) versus DIBH among patients with LML.Materials and MethodsTwenty-one patients with LML underwent 4-dimensional CT and 3 sequential DIBH scans at simulation. Involved-site radiotherapy (ISRT) target volumes and organ-at-risk contours were developed for both DIBH and FB scans. FB-IMRT, DIBH-IMRT, FB-PT, and DIBH-PT plans were generated for each patient for comparison.ResultsThe median difference in lung volume between the DIBH and FB scans was 1275mL; the average difference in CTV volume was 5.7mL. DIBH-IMRT produced a lower mean lung dose (10.8Gy vs 11.9Gy, p
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to infections such as tuberculosis. The aim of this systematic review was to find out whether there is an ...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionsShort-term exercises do not appear to convey benefits to quality of life and other psychosocial outcomes. Subgroup analysis showed that physical activity together with mental exercise may be more beneficial to lymphoma patients, but it needs more research to verify this finding. The interpretation of this result should be cautious due to the baseline difference, completion efficiency of intervention process, and high heterogeneity.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Leukemia, Published online: 21 October 2019; doi:10.1038/s41375-019-0609-3Rituximab in newly diagnosed stage IA nodular lymphocyte-predominant Hodgkin lymphoma: long-term follow-up of a phase 2 study from the German Hodgkin Study Group
Source: Leukemia - Category: Hematology Authors: Source Type: research
Leukemia, Published online: 21 October 2019; doi:10.1038/s41375-019-0611-9Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
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Source: Annals of Hematology - Category: Hematology Source Type: research
Authors: Navarro-Almenzar B, Cabañas Perianes V PMID: 31627961 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Martínez-Esteve A, Moreno-Caballero M, Jiménez-Granero P, Cobo-Rodríguez A, Infante-de-la-Torre JR, Serrano-Vicente J, Rayo-Madrid JI, Martín-Marcuartu JJ PMID: 31623822 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
We present a case study of a 74-year-old male who presented with right side flank pain and inguinal lymphadenopathy. The patient was diagnosed with low-grade follicular B-cell lymphoma with a low proliferative index (LGFL-LPI) and focal high proliferation index. Approximately 6 months later, the patient was diagnosed with LGFL-HPI with evidence of transformation into DLBCL of activated B-cell immunophenotype within the same lymph node. Separate fluorescence in situ hybridization (FISH) studies performed on the initial biopsy, the low grade component of the subsequent sample, and the transformed component of the subsequen...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Authors: Disha K, Schulz S, Breuer M, Owais T, Girdauskas E, Kuntze T Abstract Concomitant Loeys-Dietz syndrome (LDS) and hematologic malignancies are exceptionally rare. This is the first report of a patient operated on for aortic root dilation who had been previously diagnosed with LDS and B-cell-lymphoma. After completion of chemotherapy and complete remission, an elective valve-sparing aortic root replacement (using the David-V method) was performed. Due to the positive family history, pre-operative genetic counseling was conducted, and revealed LDS with a TGFBR1 (transforming growth factor beta receptor type I...
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
Publication date: Available online 19 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Domenico Albano, Rexhep Durmo, Giorgio Treglia, Raffaele Giubbini, Francesco BertagnaABSTRACTMucosa associated lymphoid tissue (MALT) lymphoma is a lymphoma involving the mucosa-associated lymphoid tissue potentially arising from any mucosal site with stomach as most common site of involvement. MALT lymphoma is usually a not aggressive disease with good prognosis except of selected cases. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a non-invasive imaging tool use...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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