A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma

Publication date: May 2019Source: Journal of Comparative Pathology, Volume 169Author(s): S. de Brot, L. Grau-Roma, C. Stirling-Stainsby, M. Dettwiler, F. Guscetti, D. Meier, T. Scase, B.D. Robinson, D. Gardner, N.P. MonganSummaryCanine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly characterized in canine UC and their role as prognostic factors is unknown. The aims of this study were to (1) assess histologically 381 canine UCs, with emphasis on myxoid tumour stroma, inflammation and necrosis and (2) assess possible associations between these features and the available epidemiological data as well as bladder wall muscle invasion. In 103 of 381 (27%) cases, the stroma was mixed collagenous and myxoid (fibromyxoid), which was strongly associated with invasive growth of muscle (P 
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research

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