Medical News Today: Scientists find possible causes for chronic kidney disease 'epidemic'

New research suggests that climate change and environmental toxins may explain the increasing prevalence of chronic kidney disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

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The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney has a unique role not only in protecting the host from heat and dehydration but also is an important site of heat-associated disease. Here we review the potential impact of global warming and heat extremes on kidney diseases. High temperatures can result in increased core temperatures, dehydration, and blood hyperosmolality. Heatstroke (both clinical and subclinical whole-body hyperthermia) may have a major role in causing both acute kidney dise...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
This study was deemed feasible with 80% enrolment and 90% completion of the protocol. Among the preselected workers, the enrolment rate was 91%. All subjects completed the physiological measures and blood collection and 95% completed th e urine studies. Mean time to complete data collection pre-shift was 19.1 ± 4.2 min and post-shift: 14.3 ± 4.0 min. Workers exposed to heat stress had a greater decline in estimated glomerular filtration rate compared to controls over the work shift (–13 ± 11 vs. –5 ± 7 mL/min;p #x3c; 0.01). We demonstrated the feasibility and challenges of conducting...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to emphasize the pivotal role of glucagon-like peptide 1 (GLP-1) in tackling the parallel epidemics of obesity and type 2 diabetes (T2DM).Recent FindingsGLP-1-based therapies and in particular GLP-1 receptor agonists (GLP-1 RA) have proven to be effective in lowering blood glucose and decreasing weight. GLP-1 RA not only mitigate these significant medical burdens but also result in weight loss and weight loss independent factors that decrease cardiovascular disease (CVD) and microvascular complications of T2DM, such as diabetic nephropathy.SummaryGLP-1-based therapies ...
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
Conclusions: In addition to etiological factors, great importance was assigned to aspects related to the health system response, including service delivery approaches, human resources, funding, and occupational and environmental aspects. PMID: 31093042 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Summary: Chronic kidney disease increasingly is being recognized as an important global public health problem. Interindividual susceptibility to kidney disease is high and likely is dependent on risk modulation through genetics, fetal and early childhood development, environmental circumstances, and comorbidities. Traditionally, the chronic kidney disease burden has been ascribed largely to hypertension and diabetes. Increasingly, evidence is accumulating that nontraditional risk factors may predominate in some regions and populations, contributing to epidemics of kidney disease.
Source: Seminars in Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge Attila Fintha1, Ákos Gasparics2, László Rosivall3 and Attila Sebe3,4* 12nd Department of Pathology, Semmelweis University, Budapest, Hungary 21st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary 3Department of Pathophysiology, International Nephrology Research and Training Center, Semmelweis University, Budapest, Hungary 4Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany Back in 1995, a landmark paper was published, which shaped the fi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we investigated the genetic contribution to renal disease in Tiwi Islanders by conducting a GWAS, in which associations were tested between SNP genetic variants and single measure ACR levels. A number of nominally significantly associated SNPs were identified. These SNPs did not reach genome wide significance, probably due to the small sample size. The top eight SNPs were re-tested for association in a separately collected cohort from the same population. Four of these SNPs were significantly associated with ACR in the replication sample (p
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
A drug that’s used to help control blood sugar in people with diabetes has now been shown to help prevent or slow kidney disease, which causes millions of deaths each year and requires hundreds of thousands of people to use dialysis to stay alive. Doctors say it’s hard to overstate the importance of this study, and what it means for curbing this problem, which is growing because of the obesity epidemic. The study tested Janssen Pharmaceuticals’ drug Invokana. Results were discussed Sunday at a medical meeting in Australia and published by the New England Journal of Medicine. About 30 million Americans and...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine onetime overnight Source Type: news
Guangwen Luo1†, Bailiang Li1†, Cailu Yang2†, Yutang Wang1, Xin Bian1, Wan Li1, Fei Liu1 and Guicheng Huo1* 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, China 2Department of Ultrasound, Maternal and Child Health Hospital of Dapeng New District, Shenzhen, China Modulating gut microbiota to promote host health is well recognized. Therefore, people consume dietary products containing traditional probiotics in wishing to improve their health, and they need more research-based advices on how to select products with sui...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(Boston University School of Medicine) For two decades, Nicaragua and El Salvador have seen increasing mortality from an unusual form of chronic kidney disease (CKD), also called Mesoamerican Nephropathy (MeN). The disease has disproportionately affected sugarcane and other agricultural workers, and appears to be unrelated to traditional kidney disease risk factors such as diabetes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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