Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree, characterized by stricturing bile duct disease and progression to liver fibrosis. The pathophysiology of PSC is still unknown. The concurrence with inflammatory bowel disease (IBD) in about 70% of the cases has led to the hypothesis that gut homing lymphocytes aberrantly traffic to the liver, contributing to the disease pathogenesis in patient with both PSC and IBD (PSC-IBD). The discovery of mutual trafficking pathways of lymphocytes to target tissues, and expression of gut-specific adhesion molecules and chemokines in the liver has pointed in this direction.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research

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Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from harsh external environments. The protective role of these epithelia is, in part, dependent on a remarkable capacity to restore barrier function and tissue homeostasis after injury. In response to damage, epithelial wounds repair by a series of events that integrate epithelial responses with those of resident and infiltrating immune cells including neutrophils and monocytes/macrophages. Compromise of this complex interplay predisposes to development of chronic nonhealing wounds, contributing to morbidity and mortality of many d...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
A UCLA-led research team has  found that giving mice antibiotics for 10 days prior to a liver transplant leads to better liver function after the surgery.After concluding the experiment mice, the scientists discovered data from liver transplants performed between October 2013 and August 2015 at the Ronald Reagan UCLA Medical Center, revealing that the same phenomenon appears to hold true in humans. The statistics from human patients even demonstrated that the people who were in worse health prior to their surgeries but received pre-surgery antibiotics fared better after their transplants than the patients who wer...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Intestinal fibrosis in patients with inflammatory bowel disease (IBD) is challenging to diagnose, and there are no approved antifibrotic therapies, according to a meeting summary.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Gastroenterology News Source Type: news
ConclusionThe incidence of IR was low, and premedication with steroids did not decrease the incidence of IR in this cohort of PIBD patients receiving IFX. Our results indicate that PM with steroids is not indicated in PIBD to prevent IR.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
The spectrum of paediatric gastrointestinal pathology is very wide and encompasses some diseases which overlap with those also seen in adult populations (e.g. chronic inflammatory bowel disease), whilst others are almost exclusive to children (e.g. necrotising enterocolitis). Selected topics in non-neoplastic paediatric gastrointestinal pathology are discussed. In this article, we briefly outline some specific gastrointestinal entities which may rarely be encountered in adult surgical pathology practice, including aspects of inflammation, infection, congenital abnormalities and those related to prematurity.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: paediatric pathology Source Type: research
This study proposes the positive correlation between the prevalence of STAT3 rs744166 risky allele "A" with the severity of disease in a cohort of 94 CD patients. In addition, the results suggest an increased STAT3 activity in the inflamed ileum of CD patients, compared to unaffected ileum sections. Notably, IL-23 triggers the differentiation of CD117+NKp44- ILC3s and induces the activation of STAT3 in both CD117+NKp44- and CD117-NKp44- ILC subsets, implying the involvement of STAT3 in the initiation of ILC plasticity. Moreover, carriage of STAT3 "A" risk allele exhibited a higher basal level of STAT3 t...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Holmer A, Singh S Abstract Introduction: Efficacy and safety are key aspects when choosing therapies for patients with inflammatory bowel diseases (IBD). While several randomized trials and indirect comparisons have informed the comparative efficacy of medications, there has been limited synthesis of safety of different agents. Areas covered: We focus on the overall and comparative risk of serious and opportunistic infections and malignancy of biologic and immunosuppressive therapy in IBD, based on randomized trials, open-label extension and registry studies and real-world comparative observational studies...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Authors: Laurent PB, Silvio D, Fraser C, Raja A, Kay G, Burkhard P, Taegyun K Abstract Introduction: The purpose of this review is to highlight the role of biosimilars in early treatment in IBD and introduce ways to facilitate a patient-centric switching process through multidisciplinary approach. Areas covered: We summarize existing scientific literature related to the role of biosimilars in inflammatory bowel disease in terms of early treatment and cost-saving and implementing switching process. Expert opinion: Use of anti-TNF biosimilars in patients has the potential for large drug-acquisition cost-saving, which...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Researchers at Cleveland Clinic have discovered a relationship between IBD and non-alcoholic liver disease, postulating that immune factors are involved in both the intestinal and liver lesions (see:Studies Reveal Heightened Liver Disease Rates in IBD Patients Immune-mediated factors may be involved). Below is an excerpt from the article but make note of the reference to the use of Explorsys, a research tool owned by IBM:...Cleveland Clinic researchers and their collaborators have found that patients with inflammatory bowel disease (IBD) experience higher rates of nonalcoholic fatty liver disease, nonalcoholic steatohepati...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Diagnostics Electronic Health Record (EHR) Healthcare Information Technology Healthcare Innovations Medical Research Predictive Analytics Preventive Medicine Public Health Source Type: blogs
Authors: Casellas F, Navarro E, Amil P, Barber C, Marín L, Guardiola J, Espín E, Sainz E, Aldeguer X, Gallego M, Murciano F, García-Planella E, Martín-de-Carpi J, Mendive JM, González-Mestre A Abstract INTRODUCTION: adequate knowledge of inflammatory bowel disease (IBD) is essential for a successful patient-centered management of IBD. OBJECTIVE: due to the scarcity of up-to-date tools for measuring IBD literacy, this single-center, prospective study aimed to develop and validate a new questionnaire to assess IBD-related knowledge. MATERIAL AND METHODS: the study included p...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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