Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition.

CONCLUSION: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1β and NLRP3 expression. Practical point: Madecassoside also exhibited a urate-lowering effect and a renal protective effect in hyperuricemic mice. PMID: 31084401 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31084401?dopt=Abstract

Source: Immunopharmacology and Immunotoxicology - May 17, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research