Glucocorticoid activity of adrenal steroid precursors in untreated patients with congenital adrenal hyperplasia.

CONCLUSIONS: We identified strongly elevated adrenal steroid precursor concentrations in blood from untreated CAH patients and demonstrated glucocorticoid activity of these adrenal precursors in vitro - suggesting a possible role of these precursors in the clinical phenotype of these patients. Further studies are necessary to evaluate the role of these precursors in more detail.
PMID: 31090904 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - May 14, 2019 Category: Endocrinology Authors: Engels M, Pijnenburg-Kleizen KJ, Utari A, Faradz SMH, Oude-Alink S, van Herwaarden AE, Span PN, Sweep FC, Claahsen-van der Grinten HL Tags: J Clin Endocrinol Metab Source Type: research