Exploitation of receptor tyrosine kinases by viral-encoded growth factors.

Exploitation of receptor tyrosine kinases by viral-encoded growth factors. Growth Factors. 2018 Aug;36(3-4):118-140 Authors: Lateef Z, Wise LM Abstract Receptor tyrosine kinases (RTKs) are essential components of cell communication pathways utilized from the embryonic to adult stages of life. These transmembrane receptors bind polypeptide ligands, such as growth factors, inducing signalling cascades that control cellular processes such as proliferation, survival, differentiation, motility and inflammation. Many viruses have acquired homologs of growth factors encoded by the hosts that they infect. Production of growth factors during infection allows viruses to exploit RTKs for entry and replication in cells, as well as for host and environmental dissemination. This review describes the genetic diversity amongst virus-derived growth factors and the mechanisms by which RTK exploitation enhances virus survival, then highlights how viral ligands can be used to further understanding of RTK signalling and function during embryogenesis, homeostasis and disease scenarios. PMID: 31084274 [PubMed - in process]
Source: Growth Factors - Category: Research Tags: Growth Factors Source Type: research