mTOR Inhibitors in the Treatment of Breast Cancer

Efforts to identify clinical biomarkers of response or resistance to mTOR inhibitors are ongoing. This review will summarize results of preclinical and clinical studies as well as ongoing clinical trials with mTOR or dual PI3K/mTOR inhibitors.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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How do alcohol consumption and smoking interact with familial risk for breast cancer?Breast Cancer Research
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
ConclusionsmiRNA ‐96‐5p may exert a tumor promotion role through negatively regulating tumor suppressor gene FOXO3 and promoting cell proliferation.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study evaluated the time to initiation and completion of treatment in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) vs adjuvant chemotherapy. We found that NAC did not expedite the start or completion of treatment. AbstractBackground/ObjectiveDelays in times to surgery, chemotherapy, and radiotherapy impair survival in breast cancer patients. Neoadjuvant chemotherapy (NAC) confers equivalent survival to adjuvant chemotherapy (AC), but it remains unknown which approach facilitates faster initiation and completion of treatment.MethodsWomen ≥18 years old with nonrecurrent, noninflammatory, clin...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
In conclusion, XIST interacts with miR-454 to inhibit cells proliferation, EMT and induce apoptosis in TNBC, indicating a promising treatment strategy for TNBC patients. PMID: 32098924 [PubMed - in process]
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
A distinct core ‐multitentacle nanoassembly is developed utilizing small gold nanoparticles (NPs) with limited plasmon resonance in the near‐infrared (NIR). 5 nm NPs assembled as tentacles are attached to 15 nm core using multiarm polymers. They provide an intense broadband absorbance throughout the NIR “opti cal biological window” over‐and‐above that of a core–satellite. Additionally, a strong surface‐enhanced Raman scattering enhancement makes them potential candidates for optical theranostics. AbstractOptical theranostic applications demand near ‐infrared (NIR) localized surface plasmon res...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
New observations of acoustic streaming generated by cells are reported. When an adherent cell is exposed to acoustic waves, oscillations of the cell cause microstreaming flow in the surrounding liquid. The observations suggest that the maximum streaming velocity generated by a cell increases with cell stiffness, and therefore, can be considered as a label ‐free strategy for probing cell mechanical properties. AbstractThe interaction of a sound or ultrasound wave with an elastic object, such as a microbubble, can give rise to a steady ‐state microstreaming flow in its surrounding liquid. Many microfluidic strategies for...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research
Conclusions: Patients showing a clinical benefit during 6 cisplatin-doublet chemotherapy cycles may have a sustained survival benefit from single-maintenance chemotherapy. PMID: 32098457 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Salma Begum Bhyan, YongKiat Wee, Mingyu Luo, Yining Liu, Min Zhao
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
The study found that for women with "triple-negative" breast cancer, adding Keytruda to standard chemotherapy improved their odds of responding.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Some companies are marketing the nipple aspirate test as the latest and greatest tool in early breast cancer screening. But FDA warns that the nipple aspirate test is no substitute for a mammogram. Find out why.
Source: FDA Consumer Health Information Updates - Category: Consumer Health News Authors: Source Type: news
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