Omalizumab for Chronic Urticaria in Children Less than 12 Years of Age: A Systematic Review.

Chronic urticaria (CU), defined by recurrent wheals, angioedema, or both lasting more than six weeks, is subclassified into chronic spontaneous urticaria (CSU) and inducible urticaria (IndU) 1. CU is disabling and impairs work and school performance 1. Current treatment guidelines recommend a stepwise approach starting with escalating doses of non-sedating antihistamines 1. Omalizumab (anti-IgE monoclonal antibody) is approved as an add-on therapy for patients (12 years and older) with antihistamine resistant CSU; however, omalizumab is not approved for CSU in children less than 12 years of age 2.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research

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Abstract Modern lifestyle with the increasing use of air conditioner (AC) has been linked with breathing difficulties, irritation, dryness, and other symptoms. Hence, dust mites were isolated from AC filters, which causes allergic diseases. A total of 95 dust samples were collected from AC filters from hospitals, guest house, office, school, and homes in Chandigarh, India. The highest concentration of dust mites was detected from hospitals (9/g), offices (7/g), households (6/g), guest houses (3/g), and schools (0/g). Based on the morphology of dust mites observed under a light microscope, Dermatophagoides and Acar...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Authors: Han JH, Je YJ, Yoon HJ, Ahn JG, Lee JS, Park JW, Park HJ Abstract Cryopyrin-associated periodic syndrome (CAPS) is a hereditary autoinflammatory syndrome caused by mutations in NLRP3 (encoding cryopyrin), which presents with fever, fatigue and arthralgia. Thus far, however there have been no reports of CAPS in Korea. Herein, we report 3 cases of CAPS for the first time in Korea. The first case, a 28-year-old man with recurrent urticaria, arthralgia and fever induced by cold, all of which were observed in his father, showed elevated erythrocyte sedimentation rate and C-reactive protein. He exhibited a p.Gly...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: The rate of anaphylaxis in patients with ColdU in a tropical country was lower than those reported by other studies conducted intemperate climates. On the other hand, the number of female patients, mean age at symptom onset, atopy rate, rate of concomitant chronic spontaneous urticaria and mean CTT were higher. PMID: 31172722 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU. PMID: 31172716 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Allergy to galactose-alpha-1,3-galactose (alpha-gal) presents as an IgE-mediated, yet delayed-onset hypersensitivity reaction to non-primate mammalian meat.1 Alpha-gal sensitization develops after tick bite exposure.1-3 The lone-star tick (Amblyomma americanum) represents the North American vector, spanning a relatively vast southeast, mid-west, and northeast geographic distribution.4 Allergic manifestations include urticaria/angioedema, abdominal pain/diarrhea, or anaphylaxis, occurring approximately 3-6 hours after ingestion.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Recently, new diagnostic tools and therapeutic agents have significantly increased the survival rate of cancer patients compared to that in the past. As the number of cancer survivors exposed to multiple courses of chemotherapy increases, more patients become sensitized to chemotherapeutic agents and suffer from hypersensitivity reactions (HSRs).1-3 HSRs to chemotherapeutic agents range from mild cutaneous urticaria to severe reactions, such as life-threatening anaphylaxis, and even death.4 Most HSRs are unpredictable, such that they threaten the safety of patients; moreover, they can be uncontrollable, and severe HSRs lim...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractThis review article aims to outline what is known in the pathophysiology of chronic rhinosinusitis with nasal polyposis (CRSwNP) and describe the mechanism of the biologic agents being investigated for this disease. Chronic rhinosinusitis with nasal polyposis is an inflammatory disease of the nasal and paranasal mucosa, which causes symptoms of nasal obstruction, hyposmia, and rhinorrhea. Conventional therapy for CRSwNP includes intranasal corticosteroids (INCS) and polypectomy, but INCS offer only modest benefits, and recurrence after surgery is common. Therefore, effective pharmacologic therapies for CRSwNP are b...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Chronic urticaria (CU), defined by recurrent wheals, angioedema, or both lasting more than 6 weeks, is subclassified into chronic spontaneous urticaria (CSU) and inducible urticaria (IU).1 CU is disabling and impairs work and school performance.1 Current treatment guidelines recommend a stepwise approach starting with escalating doses of nonsedating antihistamines.1 Omalizumab (anti-IgE monoclonal antibody) is approved as an add-on therapy for patients ( ≥12 years old) with antihistamine-resistant CSU; however, omalizumab is not approved for CSU in children younger than 12 years.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letter Source Type: research
Purpose of review To provide an update of the studies concerning the diagnosis and management of food additives allergy. Recent findings Additives improve specific characteristics of food products, but they may induce allergic even life-threatening reactions. Physical examination and medical history are basic to assess specific in-vivo and in-vitro tests. The only treatment for allergic patients consists in avoiding the food containing culprit additives. High-risk patients should be able to recognize severe reactions and self-manage them. Summary The prevalence of adverse reactions to food additives is low, and it ...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research
CONCLUSION: First-line management of newly-diagnosed infants with IgE-mediated CMPA with eHCF plus LGG instead of eHCF alone improves outcome, releases healthcare resources for alternative use, reduces the NHS cost of patient management and thereby affords a cost-effective dietetic strategy to the NHS. PMID: 31025591 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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