Generation of refractory schizophrenia patient-derived induced pluripotent stem cell line UJSi001-A

Publication date: Available online 9 May 2019Source: Stem Cell ResearchAuthor(s): Jing Sun, Xiaoya Zhang, Qijie Cong, Cong Wang, Dong Chen, Yincheng Wang, Xiaowen Wang, Zhenghui Yi, Shengying QinAbstractSchizophrenia is considered one of the most serious mental disorders nowadays. Approximately 30–60% of people with schizophrenia do not present adequate response to drug treatment and persist with symptoms of the disease; they are known as refractory schizophrenic people. We generated induced pluripotent stem cells (iPSCs) from a refractory schizophrenia patient by electroporation of peripheral blood mononuclear cells (PBMC) with episomal plasmids encoding OCT 4, SOX 2, NANOG, LIN 28, KLF 4 and LMYC. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, and could differentiate into the three germ layers in vivo.
Source: Stem Cell Research - Category: Stem Cells Source Type: research