Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

ConclusionsThese results demonstrated that cessation of anti-VLA-4 mAb treatment for 4  days caused a transient rebound increase in neuroinflammation. This highlights the usefulness of serial TSPO imaging in thefDTH-EAE model to better understand the rebound phenomenon.
Source: EJNMMI Research - Category: Radiology Source Type: research