Congenital Self-Healing Langerhans Cell Histiocytosis: A Rare Presentation of Blueberry Muffin Baby “Spectrum”

A case of congenital self-healing Langerhans cell histiocytosis (CSHLCH), also known as Hashimoto-Pritzker disease, is reported. The newborn presented as blueberry muffin baby at birth, showing numerous non-blanching blue-purplish and dark-red papular, nodular lesions without documented infections and systemic involvement. Histopathological and immunohistochemical findings were suggestive for Langerhans cell histiocytosis. During the first 12 weeks of life, the cutaneous lesions progressively and spontaneously regressed with some atrophic scars. One-year follow-up is negative for relapse of cutaneous lesions or systemic involvement, confirming the diagnosis of CSHLCH.Dermatopathology 2019;6:37 –40
Source: Dermatopathology - Category: Pathology Source Type: research

Related Links:

The objective of this literature review is to present the theoretical and practical aspects of extracorporeal membrane oxygenation support for respiratory and/or cardiac functions in critically ill patients.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Condition:   Langerhans Cell Histiocytosis Intervention:   Drug: Cytarabine Sponsor:   Peking Union Medical College Hospital Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Langerhans Cell Histiocytosis Intervention:   Drug: thalidomide combined with dexamethasone and cyclophosphamide Sponsor:   Peking Union Medical College Hospital Recruiting
Source: - Category: Research Source Type: clinical trials
Shalendra Singh, Shreyas Kate, Rashmi Datta, Virender SuhagIndian Journal of Anaesthesia 2019 63(10):866-868
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
ConclusionsSP is a common manifestation of PLCH, can be seen in approximately one-fourth of the patients, and has a high recurrence risk. Surgical pleurodesis leads to a substantial reduction in the SP recurrence risk. The risk of an air travel-related SP in patients with PLCH is about 2–3 per thousand flights.Trial registry clinicaltrials.govNCT03052101.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Abstract This is a case of a pediatric male who presented with a postauricular mass and pain. Computed tomography and magnetic resonance imaging suggested a diagnosis of Langerhans cell histiocytosis. Characteristic imaging findings and initial workup for Langerhans cell histiocytosis are described. PMID: 31558057 [PubMed - as supplied by publisher]
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
Condition:   Histiocytosis, Langerhans-Cell Interventions:   Other: Biospecimen Collection;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI) Not yet recruiting
Source: - Category: Research Source Type: clinical trials
More News: Babies | Blueberries | Dermatology | Histiocytosis | Langerhans Cell Histiocytosis (LCH) | Pathology