Next-generation Sequencing in the Management of Gastric and Esophageal Cancers.

Next-generation Sequencing in the Management of Gastric and Esophageal Cancers. Surg Clin North Am. 2019 Jun;99(3):511-527 Authors: Rubinstein JC, Nicolson NG, Ahuja N Abstract Next-generation sequencing has enabled genome-wide molecular profiling of gastric and esophageal malignancies at single-nucleotide resolution. The resultant genomic profiles provide information about the specific oncogenic pathways that are the likely driving forces behind tumorigenesis and progression. The abundance of available genomic data has immense potential to redefine management paradigms for these difficult disease processes. The ability to capitalize on the information provided through high-throughput sequencing technologies will define cancer care in the coming decades and could shift the paradigm from current stage-based, organ-specific treatments toward tailored regimens that target the specific culprit pathways driving individual tumors. PMID: 31047039 [PubMed - in process]
Source: The Surgical Clinics of North America - Category: Surgery Authors: Tags: Surg Clin North Am Source Type: research