Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.

CONCLUSION: Our result show, for the first time to our knowledge, that genetic variability in the leptin receptor gene may contribute significantly to the risk for PTDM in renal transplant recipients. Key messages The LEPR Gln223Arg polymorphism significantly contributes to the development of post-transplant diabetes mellitus in renal transplant recipients. The effect of the 223Arg variant on PTDM is strongly modulated by the age of the recipient. The 223Arg variant in the leptin receptor is related to higher BMI in renal transplant recipients. PMID: 31046466 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research