Asymmetric Crying Facies Syndrome

A female infant, born vaginally at 40  weeks of gestation with a birthweight of 3260 g had an Apgar score of 10 at 1 and 5 minutes. She presented with an asymmetric facial expression when crying, with the right side of her mouth deviating inferior-laterally (Figure, A and Video [available at]). At rest, her facial expre ssion was symmetric and a thinner left lower lip was noted (Figure, B). A pediatric neurologist noted intact motor, reflex, and cranial nerve functions, and she was diagnosed with asymmetric crying facies, likely because of hypoplasia of the left depressor angularis oris muscle.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Rediscovering the Physical Exam Source Type: research

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By Emily Reynolds Spend any amount of time online and you’re likely to see the same patterns repeat themselves over and over again: somebody says something offensive or controversial on social media, they’re met with anger and disgust, and they either apologise or double down. For some, this cycle has become somewhat of a career, with the garnering of outrage forming the backbone of their (often incredibly tedious) public personas. But does responding to such toxic or offensive remarks, especially en masse, actually work? Or does it simply increase sympathy for the offender, no matter how bigoted their rem...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Anger Social Twitter Source Type: blogs
Conclusion The diaphragmatic muscle thickness was related to the fall in diastolic blood pressure in the standing position. This indicates that adequate diaphragmatic muscle thickness helps to maintain intrathoracic pressure and prevents excessive drop in blood pressure in the standing position.
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research
Publication date: Available online 11 November 2019Source: Neurophysiologie CliniqueAuthor(s): Yasemin Akıncı, Furkan Asan, Melis Sohtaoğlu, Melih Tütüncü, Uğur Uygunoğlu, Sabahattin Saip, Ayşegül Gündüz, Meral E. KızıltanSummaryWe hypothesized that brainstem responses may allow detection of functional brainstem changes in patients with neuro-Behçet Disease (NBD). Thus, we recorded electrically-induced blink reflex (eBR), auditory blink reflex (aBR) and electrically-induced masseter inhibitory reflex (eMIR) in 16 patients with NBD. However, these neurophysiological tests pr...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Publication date: Available online 11 November 2019Source: Neuroscience LettersAuthor(s): Yuting Liu, Han Yin, Huan Ma, Xueju Yu, Guihao Liu, Lan Guo, Qingshan GengAbstractIndividuals with anxiety disorder often exhibit as imbalance in response to stressors.We sought to explore the relationship between physiological as well as psychological responses under acute mental stress and the severity of the disease.20 Generalized Anxiety Disorder(GAD) patients (14 males,mean age 46 ± 10 years) were confronted with the stroop test,during which salivary-α-amylase(sAA),salivary cortisol,and heart rate varia...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Publication date: Available online 12 November 2019Source: Comparative Biochemistry and Physiology Part A: Molecular &Integrative PhysiologyAuthor(s): Montana F. McLean, Matthew K. Litvak, Erin M. Stoddard, Steven J. Cooke, David A. Patterson, Scott G. Hinch, David W. Welch, Glenn T. CrossinAbstractWhite sturgeon are the largest freshwater fish in North America and are the focus of an intense catch-and-release (C&R) fishery; the effects are largely unknown. We assessed the effect of fight and handling time, water temperature, river discharge rate, and fish size on physiological and reflex impairment responses of wild w...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
Abstract BACKGROUND: Cough is a common feature of asthma, which is often resistant to inhaled corticosteroids (ICSs). The pathophysiology of this refractoriness may differ between daytime and nighttime asthmatic cough. We sought to identify factors contributing to ICS-refractory daytime and nighttime asthmatic cough. METHODS: Sixty-seven patients with asthma presenting solely or predominantly with chronic cough were prospectively enrolled from April 2012 to December 2014. At baseline and 12 weeks after ICS treatment, the capsaicin cough threshold (C2, C5) and methacholine airway sensitivity and reactivity wer...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
ConclusionNon-mechanical EXCIMER trephination seems to have advantages regarding postoperative corneal astigmatism and visual acuity compared with FEMTO trephination, especially in KC. A bigger sample size and longer follow-up are needed to evaluate the long-term impact of EXCIMER and FEMTO trephination on postoperative topographic and visual outcomes.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Catecholamines released by sympathetic nerves can activate adrenergic receptors present on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in vitro systems, murine tumor models in wild-type and genetically modified (β2-AR–/–) mice, and adoptive transfer approaches, we found that the degree of β2-AR signaling significantly influences MDSC frequency and survival in tumors and other tissues. It also modulates their expression of immunosuppressive molecules such as arginase-I and PD-L1 and alters their ability to suppress the proliferation of T cells. The regulatory funct...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractBackgroundThere are no consensus criteria for diagnosing upper urinary tract infections (UTI). Therefore, we conducted a study to assess whether bacterial colony counts of  ≥ 103 CFU/ml are optimal for diagnosing upper UTIs among infants.MethodsThis retrospective observational study included 673 patients (
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
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