Intermediate-Term Efficacy and Tolerance of Statins in Children

To evaluate the intermediate-term efficacy and tolerance of statins in children and adolescents with familial hypercholesterolemia.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research

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Cell Death &Disease, Published online: 21 November 2019; doi:10.1038/s41419-019-2109-9The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
AbstractPurpose of ReviewTo review randomized interventional clinical and imaging trials that support lower targeted atherogenic lipoprotein cholesterol goals in “extreme” and “very high” atherosclerotic cardiovascular disease (ASCVD) risk settings. Major atherosclerotic cardiovascular event (MACE) prevention among the highest risk patients with ASCVD requires aggressive management of global risks, including lowering of the fundamental atherogenic ap olipoprotein B-associated lipoprotein cholesterol particles [i.e., triglyceride-rich lipoprotein remnant cholesterol, low-density lipoprotein cholester...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
STATINS are given to people with high low-density lipoprotein and can help prevent narrowing arteries and cardiovascular disease. Do statins increase people ’s risk of dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: Our findings suggest that some subsets of XPD patients may be at risk of radiosensitivity reactions and treatment with statins and bisphosphonates may be an interesting approach of radioprotection countermeasure. Different mechanistic models were discussed to better understand the potential specificity of the p.[Arg683Trp];[Arg616Pro] XPD mutations . PMID: 31738647 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
ConclusionsThe study has provided a way out to combat the toxicity effects associated with bulk statins by synthesis of nanoparticles of statins with more efficacy, more bioavailability, more solubility and more radical scavenging capacity even in lesser dose.Graphical abstract
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Authors: El Menshawe SF, Nafady MM, Aboud HM, Kharshoum RM, Elkelawy AMMH, Hamad DS Abstract The current study aimed to encapsulate fluvastatin sodium (FVS), a member of the statins family possessing pleiotropic effects in rheumatoid arthritis (RA), into spanlastic nanovesicles (SNVs) for transdermal delivery. This novel delivery could surmount FVS associated oral encumbrances such as apparent first-pass effect, poor bioavailability and short elimination half-life, hence, accomplishing platform for management of RA. To consummate this objective, FVS-loaded SNVs were elaborated by thin film hydration method, utilizi...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
TUESDAY, Nov. 19, 2019 -- Statin therapy is not associated with increased decline in memory or cognition among older adults, according to a study published in the Nov. 26 issue of the Journal of the American College of Cardiology. Katherine Samaras,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Şener YZ, Okşul M PMID: 31738654 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
A 6-year study of 1,000 people aged 70 –90 found no difference in rates of memory or cognition decline among participants who did or did not use statins.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Statins Source Type: news
The hydroxymethyglutaryl-coenzyme A reductase inhibitors (statins) are a commonly prescribed class of medication for the treatment of hyperlipidemia and coronary artery disease. This class of medication has several proven benefits, including reduction of mortality related to coronary artery disease. A major consideration when prescribing these drugs are the potential for adverse effects, mainly myalgias, myopathy, and hepatotoxicity. In this article, we summarize current data on statin-associated hepatotoxicity and highlight that the risk of clinically significant idiosyncratic drug-induced liver injury is actually quite s...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
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