The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola.

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola. Adv Parasitol. 2019;104:113-164 Authors: Cwiklinski K, Donnelly S, Drysdale O, Jewhurst H, Smith D, De Marco Verissimo C, Pritsch IC, O'Neill S, Dalton JP, Robinson MW Abstract Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4-17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship. PMID: 31030768 [PubMed - in process]
Source: Advances in Parasitology - Category: Parasitology Authors: Tags: Adv Parasitol Source Type: research