Role of Platelet Microparticles in Blood Diseases: Future Clinical Perspectives.

Role of Platelet Microparticles in Blood Diseases: Future Clinical Perspectives. Ann Clin Lab Sci. 2019 Mar;49(2):161-170 Authors: Chen F, Liao Z, Peng D, Han L Abstract Platelet microparticles (PMPs) are released from the resting or activated platelet membrane, which includes a variety of proteins, mRNA, miRNA, lipids, and other substances. PMPs are involved in cell communication in vivo and are potential markers for multiple diseases. This narrative review focuses on the extraction, identification, and intercellular role of PMPs, with emphasis on the lesser known aspects of PMPs, namely, PMPs and complement systems, and their role in some diseases and disorders of women such as miscarriage and polycystic ovary syndrome, as well as the application of proteomics. For clinical purposes, we should first consider the importance of PMPs quantification and then what treatment should be given in response to increased quantities of PMPs as observed in many diseases. Currently, methods for quantification of PMPs are still in the experimental stages. Proteomics testing will expand biomarker discovery as well as future PMPs diagnostic and therapeutic applications. PMID: 31028059 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Tags: Ann Clin Lab Sci Source Type: research